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Hormonal Therapy after Menopause 05 mg estradiol gel 150 g intranasal estradiol Symptoms should be reassessed after 8 12 weeks of treatment and the dose adjusted if necessary [14] In about 10% of patients, especially women with premature ovarian failure (POF) or early iatrogenic menopause, a higher dose may be required [10 12,14,18]

supported, but forwarding can also be defined for optical wavelengths (lambdas), multiplexed time slots, and physical ports In traditional WAN terms, a network-to-network interface (NNI) or broadband carrier interconnect (BCI), when initiated by interprovider gateways, triggers a user-to-network interface (UNI) when edge hosts initiate the path request or routers and path setup Q2931 call establishment in a private network-tonetwork interface (PNNI) environment is one good example TL/1 commands to cross-connects are another example The UNI versus NNI distinction may not be a good one in a primarily provider environment, but it is worth distinguishing between path setup mechanisms that are primarily intended for edge devices requesting service and network elements asking for resources inside the cloud

Three major classes of progestogens are currently available, according to their origin from 17-OHprogesterone, 19-nortestosterone, 17-alpha-spironolactone (reviewed in [6]) They may interact with ve different receptors: progestinic, estrogenic, androgenic, glucocorticoid, and mineralocorticoid, with agonist, antagonist, or neutral effect [6] Their metabolic, endocrine, and sexual action can therefore be very different from one progestogen to another This is the major reason why some negative data emerging from RCTs, such as WHI, using the speci c progestogen, medroxyprogesterone acetate (MPA), with a high mineralocorticoid af nity and therefore a negative vascular pro le, should not be generalized to the whole class of progestogens [6,14,18] The choice of progestogens (progesterone or synthetic progestins) should be tailored according to the patient s therapeutic needs (androgenic, antiandrogenic, neutral) and metabolic risk pro le [6] The dose and schedule should be adjusted to: the dose of estrogens, to guarantee the endometrial protection; to the regimen preferred (continuous combined versus sequential) and to the route of administration (oral, transdermal, subcutaneous, vaginal, or intrauterine [progestogen releasing intrauterine device])

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able to improve the quality of life in elderly patients It also determines an estrogen-like restoration of endorphin basal and stimulated level, indicating a modulation of the neuroendocrine function In addition, the positive effect on Kuppermann score (which quanti es the severity of menopausal symptoms), with no changes on endometrial thickness, suggests that DHEA administration in the postmenopause may be considered as a possible real replacement treatment [20] However, no androgenic treatment for the menopause has yet been approved at the time of writing (November 2005)